Allegra Geller, the leading game designer in the world, is testing her new virtual reality game, eXistenZ with a focus group. As they begin, she is attacked by a fanatic assassin employing a bizarre organic gun. She flees with a young marketing trainee, Ted Pikul, who is suddenly assigned as her bodyguard. Unfortunately, her pod, an organic gaming device that contains the only copy of the eXistenZ game program, is damaged. To inspect it, she talks Ted into accepting a gameport in his own body so he can play the game with her. The events leading up to this, and the resulting game lead the pair on a strange adventure where reality and their actions are impossible to determine from either their own or the games perspective. 这是一个虚拟实境的系统，所采用的科技，进步到包含生物学。它远远超越时代。 游戏的设计者爱丽拉盖勒美丽性感，是电玩界的女王，对自己所设计的游戏，她一向全心投入。 X接触之所以那么真实，是因为它的驱动器，是一种类器官，可直接插入玩家的神经系统。这个驱动器可以影响玩家的记忆、焦虑与专注力，玩的人不同，游戏的方向就不同。 在试玩大会上，各方玩家齐聚一堂，体验爱丽拉的最新杰作。想不到半徒杀进一群反X接触的人，以一种奇怪的武器破坏驱动器。在一片混乱中，爱丽拉被泰德皮库救走。泰德在公司里职位很低，这次在试玩大会上...
